Fibromyalgia Treatment
Ketamine for Fibromyalgia Treatment
Once known only as an FDA-approved anesthetic, ketamine is now a breakthrough treatment for chronic pain conditions like fibromyalgia. When infused at low doses, IV ketamine can significantly reduce pain by targeting the nervous system dysfunction at the root of fibromyalgia rather than just masking symptoms.

Fibromyalgia is a complex condition causing widespread pain, fatigue, and cognitive issues, often resistant to traditional treatments. Unlike medications that offer temporary relief, ketamine works neurologically to recalibrate pain perception and restore balance to an overactive nervous system.
At Scottsdale Ketamine Therapy Clinic, we provide physician-led ketamine therapy for those who haven’t found relief through conventional methods. If nothing else has worked, ketamine therapy offers a new approach, one rooted in neuroscience and patient-centered care.
How Does Ketamine Help with Fibromyalgia?
Fibromyalgia is classified as a central pain syndrome, meaning that the pain is not caused by an injury or tissue damage but by faulty pain signaling within the nervous system. The brain and spinal cord amplify pain responses, causing even mild sensations to be interpreted as severe discomfort.
Traditional treatments—including opioids, NSAIDs, muscle relaxants, and antidepressants—fail to address the neurological root cause of fibromyalgia. These medications often provide minimal relief, significant side effects, and little long-term benefit.
Ketamine works differently. It modulates the central nervous system, helping to reset the brain’s pain pathways and alleviate the overwhelming pain responses associated with fibromyalgia.
Ketamine’s Mechanism for Fibromyalgia Relief
- NMDA Receptor Blockade – The NMDA receptor plays a key role in learning and memory. These receptors are key players in chronic pain conditions. In fibromyalgia, this receptor is overactive, leading to hypersensitivity to pain. Ketamine blocks NMDA receptors, disrupting the cycle of pain amplification.
- Nervous System Reset – Ketamine has a unique ability to disrupt abnormal pain signaling in the brain and spinal cord, helping to reset the overactive pain response that characterizes fibromyalgia.
- Reduction of Central Sensitization – Over time, fibromyalgia patients develop central sensitization, a state in which the nervous system remains in constant overdrive, amplifying pain signals. Ketamine helps reverse this process, bringing the nervous system back to a more balanced state.
- Mood Stabilization and Emotional Relief – Many fibromyalgia sufferers experience co-existing anxiety, depression, and emotional distress, which can exacerbate pain perception. Ketamine’s rapid antidepressant effects help address the emotional burden of fibromyalgia, often leading to significant pain relief as mental well-being improves.
- Neuroplasticity and Healing – Ketamine enhances neuroplasticity, the brain’s ability to rewire itself and form new, healthier connections. By interrupting maladaptive pain pathways, ketamine offers a long-term shift in pain perception rather than just temporary symptom relief.
Is Ketamine Right For My Fibromyalgia?
The decision to pursue ketamine therapy for fibromyalgia should be based on individualized assessment and treatment goals. While ketamine is not a cure, many fibromyalgia patients report significant pain reduction, improved mood, and enhanced overall function after treatment.
Who Might Benefit from Ketamine for Fibromyalgia?
- Individuals who have not found relief with traditional treatments, including medications, physical therapy, and alternative therapies.
- Those experiencing chronic pain, fatigue, and brain fog that significantly impact daily life.
- Patients struggling with co-existing mental health conditions such as depression, anxiety, or PTSD, which often accompany fibromyalgia.
- Individuals looking for a treatment that works at the neurological level, rather than just masking symptoms.
Ketamine therapy represents a paradigm shift in fibromyalgia treatment, addressing the neurological origins of chronic pain rather than simply dulling symptoms. At Gilbert Chandler Ketamine Therapy Clinic and Scottsdale Ketamine Therapy Clinic, our goal is to help patients reclaim their lives from the grip of fibromyalgia through science-backed, patient-centered care.
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We provide complimentary consultation on a phone call. One of our experienced doctors will discuss your concerns and provide guidance.
Call us on 480-253-9710 (Scottsdale) or 480-256-9322 (Gilbert), or fill the form below to receive a call back